logo

A Dependable Solution for Each Patient's Unique Need

RELEXXII (methylphenidate hydrochloride extended-release tablets) is available in a range of dosing options for easy titration to achieve the necessary therapeutic range. This means you can harness an ideal dose to help patients get the therapy they need in a convenient, affordable once-daily solution.

Not actual patients. For illustrative purposes only.

Joey, Age 14

Titration 18-mg + 18-mg + 9 additional mg = 45-mg (in one daily dose)

Diagnosis: ADHD

Current Medications: Joey started on 18-mg of RELEXXII six months ago and was titrated to 36-mg. The doctor does not want to move Joey all the way up to 54-mg, so the RELEXXII once-daily "in-between" dose of 45-mg provides a better option to titrate more gradually as the next step.

Situation: ADHD symptoms have improved, but a dose adjustment may provide better control. Joey requires titration to 45-mg daily and is resistant to taking multiple tablets.

Josh, Age 20

Quantity Limit = 30 Tablets

Diagnosis: ADHD

Current Medications: 63-mg in two tablets daily (18-mg methylphenidate + 45-mg RELEXXII)

Situation: Josh's insurance coverage imposes a monthly quantity limit of 30 tablets. Taking a single once-daily 63-mg RELEXXII tablet not only brings Josh within the monthly quantity limit, it also reduces his monthly prescription out-of-pocket cost while offering the reliability of a branded medication.

Isabella, Age 18

1 Manufacturer =
Same Appearance

Diagnosis: ADHD and generalized anxiety disorder

Current Medications: 63-mg (1x27-mg + 1x36-mg) methylphenidate tablets daily

Situation: Isabella is concerned about receiving tablets for her ADHD that vary in shape, size, and color from fill to fill. She would prefer a predictable, reliable branded product month-to-month so there are no surprises. Isabella's doctor heard her concern and switched her to 63-mg once-daily RELEXXII.

Alex, Age 30

Convenience = One 72-mg tablet
versus two 36-mg tablets

Diagnosis: ADHD

Current Medications: (2x36-mg) methylphenidate tablets daily

Situation: Alex prefers the convenience of taking one 72-mg RELEXXII tablet daily versus two 36-mg tablets daily. He also prefers to pay one monthly co-pay instead of two.

Pay as Little as $15 per Month with the RELEXXII® Savings Card*

Pharmacokinetic Study:
RELEXXII Once-Daily Dosing Equivalency

The study exhibits how a once-daily RELEXXII (methylphenidate hydrochloride extended-release tablets) 72-mg works as effectively as twice-daily doses.

RELEXXII 72-mg has demonstrated bioequivalence to two 36-mg Concerta® (methylphenidate HCl) tablets.2

Pharmacokinetic study of mean methylphenidate plasma concentration over time — Administration of one RELEXXII 72-mg tablet versus two 36-mg Concerta® tablets.2

Per revised FDA guidance in 2014, additional bioequivalence metrics are required to ensure that a new methylphenidate extended-release alternative is therapeutically equivalent to Concerta® tablets.3

  • 36
  • 36
  • 72

Demonstrated bioequivalence to two 36-mg Concerta® (methylphenidate HCl) tablets2

  • Metrics
  • meets fda bioequivalent criteria3
  • Cmax
  • AUC(0-∞)
  • AUC(0-3)
  • AUC(3-7)
  • AUC(7-12)

Concerta® is a registered trademark of ALZA Corporation.

References: 1. RELEXXII (methylphenidate hydrochloride extended-release tablets) package insert. Vertical Pharmaceuticals, LLC; 2023. 2. Data on file, Osmotica Pharmaceutical US LLC. 3. US Food and Drug Administration. Draft Guidance on Methylphenidate Hydrochloride. Revised November 2014. Accessed July 2018.

*Co-pay assistance is applicable to prescription coverage for eligible commercially insured patients. Offer void where prohibited. No income restrictions apply. Other restrictions may apply. For full terms and conditions, click here.

All individuals depicted are models used for illustrative purposes only.