How It Works: Once-Daily RELEXXII® Methylphenidate HCl ER for ADHD

How Osmodex^® delivers long-acting ADHD medication throughout the day

Osmodex^® Drug Delivery Technology video is for illustrative purposes only. The technology applies to all seven strengths.

Osmodex^® delivers long-acting ADHD medication by steadily releasing methylphenidate HCl throughout the day.

Unlike short-acting medications that may wear off quickly, RELEXXII combines an immediate-release layer for quick relief with an extended-release layer that may help provide consistent symptom control from morning through evening.^1,2

The tablet uses osmotic pressure to gradually deliver medication at a controlled rate throughout the day

How extended-release methylphenidate works with Osmodex: the immediate-release layer dissolves within 1 hour, then water entering the semipermeable membrane expands the osmotic push layer, releasing the extended-release layer through a laser-drilled orifice

How RELEXXII's extended-release delivery is designed to work

Once-daily RELEXXII extended-release tablets provide a steady, more consistent effect, reducing the highs and lows associated with taking immediate-release methylphenidate HCI three times daily.¹

This graph is for illustrative purposes only. It is based on 54 mg pharmacokinetic data from a study of 36 healthy participants aged 18-65.^2,3 Individual responses, including the timing of drug absorption, drug concentration levels, and duration of effect, may vary.

Illustrative graph of long-acting ADHD medication levels over 24 hours with RELEXXII: onset within 1 hour, peak around 6 hours, coverage into the evening and a controlled taper before the next morning dose

Rapid Symptom Relief

Medication begins working within an hour of administration.
Support During Peak Daily Demands

RELEXXII helps control ADHD symptoms when it matters most, including the important 7–12 hour period after taking a morning dose.^1,3
Consistent All Day Coverage

Designed to deliver therapeutic blood levels throughout the day into the evening.²
Smooth, Controlled Taper as the Day Winds Down

Medication levels gradually taper, reducing the potential for a sudden crash before the next morning's dose.

Parent and child climbing an indoor rock wall together

Could RELEXXII be right for you or your child?

Everyone’s ADHD treatment needs are different. Learn who may benefit from a once-daily, long-acting extended-release methylphenidate option.

WHO’S RIGHT FOR RELEXXII

References: 1. RELEXXII package insert. Vertical Pharmaceuticals, LLC. 2. Data on file, Osmotica Pharmaceuticals. 3. Childress AC, et al. Clin Pharmacol Drug Dev. 2025;0(0):1-7.

All individuals depicted are models used for illustrative purposes only.

ADHD=attention deficit hyperactivity disorder